How to remove the Door Handle, Door Latch Assembly and Door Lock Cylinder on Lexus RX350?

Do put on gloves while working around the door opening to avoid cuts from the sharp metal edges. To take out the door latch, open the window and remove the door trim panel and watershield. Disengage the rods from the handle and lock cylinder through the large access hole. At the latch, cut off all electrical connectors and release all handle-to-latch cables. Unscrew and lift out those latches that have been screwed into their places within doors. To remove outside handle and door lock cylinder assembly, raise window and remove door trim panel and watershield. Work via hi aperture unclip plastic fasteners securing outside door lock to latch rod and outside door handle to latch rod. Take plug out of end of door, remove screw holding in lock cylinder. Unfasten bolts holding handle onto inside of door; remove handle frame with it. For inside door handle removal take off door trim panel first. Remove screws that fixate handles into place in a panel.

Genuine Lexus RX350 Door Lock Cylinder

Door Lock Cylinder Tumbler

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25 Door Lock Cylinders found

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Lexus RX350 Door Lock Cylinder & Key Set Left
Part Number: 69052-0E010
$110.44 MSRP: $149.35
You Save: $38.91 (27%)
Ships in 1-3 Business Days
ADD TO CART
Product Specifications
- Other Name: Cylinder & Key Set, Door Lock, Lh; Cylinder & Keys, Lock Cylinder
- Position: Driver Side
- Replaces: 69052-48080
- Warranty: This genuine part is guaranteed by Lexus's factory warranty.
Fits the following Vehicles:
- 2007-2009 Lexus RX350 | STD | 6 Cyl 3.3L, 6 Cyl 3.5L | 2GRFE, 3MZFE; GSU30L-AWAGKA, 3MZFE; GSU30L-CWAGKA, GSU35L-AWAGKA, GSU35L-CWAGKA, MCU33L-AWAGKA, MCU33L-CWAGKA, MCU38L-AWAGKA, MCU38L-CWAGKA
View related parts
Lexus RX350 Cylinder & Key Set, Ignition Switch Lock
Part Number: 69057-0E011
$242.65 MSRP: $330.82
You Save: $88.17 (27%)
Ships in 1-3 Business Days
ADD TO CART
Product Specifications
- Replaces: 69057-0E010, 69057-60470
- Warranty: This genuine part is guaranteed by Lexus's factory warranty.
Fits the following Vehicles:
- 2007-2009 Lexus RX350 | STD | 6 Cyl 3.3L, 6 Cyl 3.5L | 2GRFE, 3MZFE; GSU30L-CWAGKA, GSU35L-CWAGKA, MCU33L-CWAGKA, MCU38L-CWAGKA
View related parts
Lexus RX350 Cylinder & Key Set, Ignition Switch Lock
Part Number: 69057-48160
$387.09 MSRP: $527.77
You Save: $140.68 (27%)
Ships in 1-3 Business Days
ADD TO CART
Product Specifications
- Replaced by: 69057-48101
- Warranty: This genuine part is guaranteed by Lexus's factory warranty.
Fits the following Vehicles:
- 2007-2009 Lexus RX350 | STD | 6 Cyl 3.3L, 6 Cyl 3.5L | 2GRFE, 3MZFE; GSU30L-AWAGKA, GSU35L-AWAGKA, MCU33L-AWAGKA, MCU38L-AWAGKA
View related parts
Lexus RX350 Door Lock Cylinder & Key Set Left
Part Number: 69052-48110
$163.83 MSRP: $223.37
You Save: $59.54 (27%)
Ships in 1-3 Business Days
ADD TO CART
Product Specifications
- Other Name: Cylinder & Key Set, Door Lock, Lh; Cylinder & Keys, Lock Cylinder
- Position: Driver Side
- Warranty: This genuine part is guaranteed by Lexus's factory warranty.
Fits the following Vehicles:
- 2010-2015 Lexus RX350 | STD | 6 Cyl 3.5L | 2GRFE, 2GRFXE; GGL10L-AWTGKA, GGL10L-CWTGKA, GGL15L-AWTGKA, GGL15L-CWTGKA, GGL15L-CWZGKA, GYL10L-AWXGKA, GYL10L-CWXGKA, GYL15L-AWXGKA, GYL15L-CWXGKA
View related parts
Lexus RX350 Cylinder & Key Set
Part Number: 69005-0E220
$180.06 MSRP: $243.50
You Save: $63.44 (27%)
Ships in 1-3 Business Days
ADD TO CART
Product Specifications
- Other Name: Cylinder Set, Lock
- Replaces: 69005-48570
- Warranty: This genuine part is guaranteed by Lexus's factory warranty.
Fits the following Vehicles:
- 2016-2020 Lexus RX350 | STD | 6 Cyl 3.5L | 2GRFKS, 2GRFXS; GGL20L-CWZGBA, 2GRFXS; GGL25L-AWZGBA, GGL25L-BWZGBA, GGL25L-CWZGBA, GYL20L-CWXGBA, GYL25L-AWXGBA, GYL25L-CWXGBA
View related parts
Lexus RX350 Door Lock Cylinder & Key Set Left
Part Number: 69052-48080
$112.24 MSRP: $149.35
You Save: $37.11 (25%)
Ships in 1-3 Business Days
ADD TO CART
Product Specifications
- Other Name: Cylinder & Key Set, Door Lock, Lh
- Position: Driver Side
- Replaced by: 69052-0E010
- Warranty: This genuine part is guaranteed by Lexus's factory warranty.
Fits the following Vehicles:
- 2007-2009 Lexus RX350 | STD | 6 Cyl 3.3L, 6 Cyl 3.5L | 2GRFE, 3MZFE; GSU30L-AWAGKA, GSU35L-AWAGKA, MCU33L-AWAGKA, MCU38L-AWAGKA
View related parts
Lexus RX350 Door Lock Cylinder & Key Set Left
Part Number: 69052-48120
$159.93 MSRP: $218.05
You Save: $58.12 (27%)
Ships in 1-3 Business Days
ADD TO CART
Product Specifications
- Other Name: Cylinder & Key Set, Door Lock, Lh; Cylinder & Keys
- Position: Driver Side
- Warranty: This genuine part is guaranteed by Lexus's factory warranty.
Fits the following Vehicles:
- 2010-2015 Lexus RX350 | STD | 6 Cyl 3.5L | 2GRFE, 2GRFXE; GGL10L-AWTGKA, GGL10L-CWTGKA, GGL15L-AWTGKA, GGL15L-CWTGKA, GGL15L-CWZGKA, GYL10L-AWXGKA, GYL10L-CWXGKA, GYL15L-AWXGKA, GYL15L-CWXGKA
View related parts
Lexus RX350 Door Lock Cylinder & Key Set Left
Part Number: 69052-0E130
$140.90 MSRP: $192.11
You Save: $51.21 (27%)
Ships in 1-3 Business Days
ADD TO CART
Product Specifications
- Other Name: Cylinder & Key Set, Door Lock, Lh; Cylinder & Keys, Lock Cylinder
- Position: Driver Side
- Replaces: 69052-48100
- Warranty: This genuine part is guaranteed by Lexus's factory warranty.
Fits the following Vehicles:
- 2016-2020 Lexus RX350 | STD | 6 Cyl 3.5L | 2GRFKS, 2GRFXS; GGL20L-CWZGBA, 2GRFXS; GGL25L-AWZGBA, GGL25L-BWZGBA, GGL25L-CWZGBA, GYL20L-CWXGBA, GYL25L-AWXGBA, GYL25L-CWXGBA
View related parts
Lexus RX350 Cylinder & Key Set
Part Number: 69005-48640
$170.18 MSRP: $232.02
You Save: $61.84 (27%)
Ships in 1-2 Business Days
ADD TO CART
Product Specifications
- Warranty: This genuine part is guaranteed by Lexus's factory warranty.
Fits the following Vehicles:
- 2023-2025 Lexus RX350 | 4 Cyl 2.4L, 4 Cyl 2.5L | A25AFXS, T24AFTS; AALH15L-AWXGBA, AALH16L-AWXGBA, TALA10L-AWZGTA, TALH17L-AWTGTA
View related parts
Lexus RX350 Cylinder & Key Set
Part Number: 69052-48210
$140.17 MSRP: $191.11
You Save: $50.94 (27%)
Ships in 1-2 Business Days
ADD TO CART
Product Specifications
- Other Name: Cylinder & Key
- Position: Driver Side
- Warranty: This genuine part is guaranteed by Lexus's factory warranty.
Fits the following Vehicles:
- 2023-2025 Lexus RX350 | 4 Cyl 2.4L, 4 Cyl 2.5L | A25AFXS, T24AFTS; AALH15L-AWXGBA, AALH16L-AWXGBA, TALA10L-AWZGTA, TALH17L-AWTGTA
View related parts
Lexus RX350 Cylinder & Key Set
Part Number: 69005-0E011
$572.66 MSRP: $780.76
You Save: $208.10 (27%)
Ships in 1-3 Business Days
ADD TO CART
Product Specifications
- Other Name: Cylinder Set, Lock
- Replaces: 69005-0E010, 69005-48120
- Warranty: This genuine part is guaranteed by Lexus's factory warranty.
Fits the following Vehicles:
- 2007-2009 Lexus RX350 | STD | 6 Cyl 3.3L, 6 Cyl 3.5L | 2GRFE, 3MZFE; GSU30L-CWAGKA, GSU35L-CWAGKA, MCU33L-CWAGKA, MCU38L-CWAGKA
View related parts
Lexus RX350 Cylinder & Key Set
Part Number: 69052-0E190
$131.26 MSRP: $178.96
You Save: $47.70 (27%)
Ships in 1-2 Business Days
ADD TO CART
Product Specifications
- Other Name: Lock Cylinder
- Position: Driver Side
- Warranty: This genuine part is guaranteed by Lexus's factory warranty.
Fits the following Vehicles:
- 2023-2025 Lexus RX350 | 4 Cyl 2.4L, 4 Cyl 2.5L | A25AFXS, T24AFTS; AALH15L-CWXGBA, TALA10L-CWZGTA, TALA15L-CWZGTA, TALH17L-CWTGTA
View related parts
Lexus RX350 Cylinder & Key Set
Part Number: 69052-0E131
$140.17 MSRP: $191.11
You Save: $50.94 (27%)
Ships in 1-3 Business Days
ADD TO CART
Product Specifications
- Other Name: Lock Cylinder
- Position: Driver Side
- Warranty: This genuine part is guaranteed by Lexus's factory warranty.
Fits the following Vehicles:
- 2019-2022 Lexus RX350 | 6 Cyl 3.5L | 2GRFKS, 2GRFXS; GGL20L-CWZGBA, GGL25L-CWZGBA, GYL25L-CWXGBA
View related parts
Lexus RX350 Cylinder & Key Set
Part Number: 69052-48101
$140.17 MSRP: $191.11
You Save: $50.94 (27%)
Ships in 1-3 Business Days
ADD TO CART
Product Specifications
- Other Name: Cylinder & Keys, Lock Cylinder
- Position: Driver Side
- Warranty: This genuine part is guaranteed by Lexus's factory warranty.
Fits the following Vehicles:
- 2019-2022 Lexus RX350 | STD | 6 Cyl 3.5L | 2GRFKS, 2GRFXS; GGL25L-AWZGBA, GGL25L-BWZGBA, GYL25L-AWXGBA
View related parts
Lexus RX350 Door Lock Cylinder & Key Set Left
Part Number: 69052-48100
$142.05 MSRP: $192.11
You Save: $50.06 (27%)
Ships in 1-3 Business Days
ADD TO CART
Product Specifications
- Other Name: Cylinder & Key Set, Door Lock, Lh
- Position: Driver Side
- Replaced by: 69052-0E130
- Warranty: This genuine part is guaranteed by Lexus's factory warranty.
Fits the following Vehicles:
- 2016-2020 Lexus RX350 | STD | 6 Cyl 3.5L | 2GRFKS, 2GRFXS; GGL25L-AWZGBA, GGL25L-BWZGBA, GYL25L-AWXGBA
View related parts
Lexus RX350 Cylinder & Key Set
Part Number: 69005-0E270
$170.91 MSRP: $233.02
You Save: $62.11 (27%)
Ships in 1-2 Business Days
ADD TO CART
Product Specifications
- Warranty: This genuine part is guaranteed by Lexus's factory warranty.
Fits the following Vehicles:
- 2023-2025 Lexus RX350 | 4 Cyl 2.4L, 4 Cyl 2.5L | A25AFXS, T24AFTS; AALH15L-CWXGBA, TALA10L-CWZGTA, TALA15L-CWZGTA, TALH17L-CWTGTA
View related parts
Lexus RX350 Cylinder & Key Set
Part Number: 69005-0E221
$205.15 MSRP: $277.43
You Save: $72.28 (27%)
Ships in 1-3 Business Days
ADD TO CART
Product Specifications
- Warranty: This genuine part is guaranteed by Lexus's factory warranty.
Fits the following Vehicles:
- 2019-2022 Lexus RX350 | 6 Cyl 3.5L | 2GRFKS, 2GRFXS; GGL20L-CWZGBA, GGL25L-CWZGBA, GYL25L-CWXGBA
View related parts
Lexus RX350 Cylinder & Key Set
Part Number: 69005-48570
$180.06 MSRP: $243.50
You Save: $63.44 (27%)
Ships in 1-3 Business Days
ADD TO CART
Product Specifications
- Other Name: Cylinder Set, Lock
- Replaced by: 69005-0E220
- Warranty: This genuine part is guaranteed by Lexus's factory warranty.
Fits the following Vehicles:
- 2016-2020 Lexus RX350 | STD | 6 Cyl 3.5L | 2GRFKS, 2GRFXS; GGL25L-AWZGBA, GGL25L-BWZGBA, GYL25L-AWXGBA
View related parts
Lexus RX350 Cylinder & Key Set
Part Number: 69005-48571
$183.26 MSRP: $247.83
You Save: $64.57 (27%)
Ships in 1-3 Business Days
ADD TO CART
Product Specifications
- Warranty: This genuine part is guaranteed by Lexus's factory warranty.
Fits the following Vehicles:
- 2019-2022 Lexus RX350 | STD | 6 Cyl 3.5L | 2GRFKS, 2GRFXS; GGL25L-AWZGBA, GGL25L-BWZGBA, GYL25L-AWXGBA
View related parts
Lexus RX350 Cylinder & Key Set
Part Number: 69005-0E020
$225.32 MSRP: $304.70
You Save: $79.38 (27%)
Ships in 1-3 Business Days
ADD TO CART
Product Specifications
- Other Name: Cylinder Set, Lock
- Replaces: 69005-48410
- Warranty: This genuine part is guaranteed by Lexus's factory warranty.
Fits the following Vehicles:
- 2010-2015 Lexus RX350 | STD | 6 Cyl 3.5L | 2GRFE, 2GRFXE; GGL10L-AWTGKA, 2GRFXE; GGL10L-CWTGKA, GGL15L-AWTGKA, GGL15L-CWTGKA, GGL15L-CWZGKA, GYL10L-AWXGKA, GYL10L-CWXGKA, GYL15L-AWXGKA, GYL15L-CWXGKA

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Lexus RX350 Door Lock Cylinder

Lexus RX350 Door Lock Cylinder is the key-operated access that allows the driver to lock or unlock the cabin with a simple twist of the metal key, ensuring that entry to the cabin remains simple and safe. Mounted on the inside of each front door, the Door Lock Cylinder accommodates the slot in which the key goes and then couples with the internal latch bars to either free or anchor the lock, preventing it from being opened when the Lexus is not in use. Every turn moves small tumblers that must match the key's unique grooves, a tried and trusted mechanical method that the RX350 line has continued to use even as the modern age has banished external keyholes from some vehicles. Across model years, the style does not change much, so owners find the same dependable feel whether they are buying an early or current model of the SUV, with the principal distinction between them being updated exterior trim contours that surround the Door Lock Cylinder without affecting how it works. Because all Door Lock Cylinders in a Lexus RX350 are turned daily, lubrication is important. Regular use eventually wears the Door Lock Cylinder components, resulting in stiff motion or a stuck key, indicating that replacement can ensure any Lexus RX350 continues to feel effortless and secure. Additionally, maintaining the Door Lock Cylinder is crucial for long-term reliability.

Should you need to purchase new auto parts for your vehicle, we strongly suggest you consider the genuine Lexus RX350 Door Lock Cylinder available on LexusPartsNow.com. Our OEM Lexus RX350 Door Lock Cylinder come with the reassurance of the manufacturer's warranty, a hassle-free return policy, and speedy delivery service, all at affordable prices online. Feel free to shop with confidence!

Lexus RX350 Door Lock Cylinder Parts Questions & Experts Answers

Cylinder & Key Set, Ignition Switch Lock
69057-48160
Q: How to remove the Door Handle, Door Latch Assembly and Door Lock Cylinder on Lexus RX350?
A:
Do put on gloves while working around the door opening to avoid cuts from the sharp metal edges. To take out the door latch, open the window and remove the door trim panel and watershield. Disengage the rods from the handle and lock cylinder through the large access hole. At the latch, cut off all electrical connectors and release all handle-to-latch cables. Unscrew and lift out those latches that have been screwed into their places within doors. To remove outside handle and door lock cylinder assembly, raise window and remove door trim panel and watershield. Work via hi aperture unclip plastic fasteners securing outside door lock to latch rod and outside door handle to latch rod. Take plug out of end of door, remove screw holding in lock cylinder. Unfasten bolts holding handle onto inside of door; remove handle frame with it. For inside door handle removal take off door trim panel first. Remove screws that fixate handles into place in a panel.

Related Lexus RX350 Parts

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2025 Door Lock Cylinder 2024 Door Lock Cylinder 2023 Door Lock Cylinder 2022 Door Lock Cylinder 2021 Door Lock Cylinder 2020 Door Lock Cylinder 2019 Door Lock Cylinder 2018 Door Lock Cylinder 2017 Door Lock Cylinder 2016 Door Lock Cylinder 2015 Door Lock Cylinder 2014 Door Lock Cylinder 2013 Door Lock Cylinder 2012 Door Lock Cylinder 2011 Door Lock Cylinder 2010 Door Lock Cylinder 2009 Door Lock Cylinder 2008 Door Lock Cylinder 2007 Door Lock Cylinder