How to remove and install A/C Compressor on Lexus RX350?

The receiver/drier should be replaced whenever the compressor is replaced. First, have the refrigerant discharged by an automotive air conditioning technician. Next, disconnect the negative cable from the battery. Remove the drivebelt from the compressor and take off the splash shield from below the engine compartment, if equipped. For 2003 and earlier Lexus models, remove the alternator. For 2008 and later Highlander models and 2009 and later RX 350 models, remove the radiator. Detach the wiring connector and the refrigerant lines, then unbolt the compressor and lift it from the vehicle. If a new or rebuilt compressor is being installed, follow the directions that come with it regarding the proper level of oil prior to installation. Installation is the reverse of removal; replace any O-rings with new ones specifically made for the purpose and lubricate them with refrigerant oil. Finally, have the system evacuated, recharged, and leak tested by the shop that discharged it.

Genuine Lexus RX350 A/C Compressor

Air Conditioning Compressor

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20 A/C Compressors found

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Lexus RX350 Compressor Assy, W/Motor
Part Number: 88370-48030
$499.13 MSRP: $692.90
You Save: $193.77 (28%)
Ships in 1-3 Business Days
ADD TO CART
Product Specifications
- Other Name: Compressor
- Warranty: This genuine part is guaranteed by Lexus's factory warranty.
Fits the following Vehicles:
- 2010-2012 Lexus RX350 | STD | 6 Cyl 3.5L | 2GRFXE; GYL10L-AWXGKA, GYL15L-AWXGKA
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Lexus RX350 Compressor Assembly
Part Number: 88320-48320
$483.23 MSRP: $670.82
You Save: $187.59 (28%)
Ships in 1-3 Business Days
ADD TO CART
Product Specifications
- Other Name: Compressor Assy, Cooler; Compressor
- Manufacturer Note: MEXICO SPEC
- Warranty: This genuine part is guaranteed by Lexus's factory warranty.
Fits the following Vehicles:
- 2016-2022 Lexus RX350 | STD | 6 Cyl 3.5L | 2GRFKS; GGL20L-CWZGBA, GGL25L-AWZGBA, GGL25L-BWZGBA, GGL25L-CWZGBA
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Lexus RX350 Compressor Assembly
Part Number: 88320-48280
$675.95 MSRP: $876.93
You Save: $200.98 (23%)
Ships in 1-3 Business Days
ADD TO CART
Product Specifications
- Other Name: Compressor Assy, Cooler; Compressor
- Replaces: 88320-48260
- Warranty: This genuine part is guaranteed by Lexus's factory warranty.
Fits the following Vehicles:
- 2012-2015 Lexus RX350 | STD | 6 Cyl 3.5L | 2GRFE; GGL10L-AWTGKA, GGL10L-CWTGKA, GGL15L-AWTGKA, GGL15L-CWTGKA, GGL15L-CWZGKA
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Lexus RX350 Compressor Assembly
Part Number: 88320-48120
$505.67 MSRP: $690.51
You Save: $184.84 (27%)
Ships in 1-3 Business Days
ADD TO CART
Product Specifications
- Other Name: Compressor Assy, Cooler
- Replaced by: 88320-48120-84
- Warranty: This genuine part is guaranteed by Lexus's factory warranty.
Fits the following Vehicles:
- 2007-2009 Lexus RX350 | STD | 6 Cyl 3.5L | 2GRFE; GSU30L-AWAGKA, GSU30L-CWAGKA, GSU35L-AWAGKA, GSU35L-CWAGKA
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Lexus RX350 Compressor Assembly
Part Number: 88320-48170
$689.03 MSRP: $959.37
You Save: $270.34 (29%)
Ships in 1-3 Business Days
ADD TO CART
Product Specifications
- Other Name: Compressor Assy, Cooler
- Replaced by: 88320-48220
- Warranty: This genuine part is guaranteed by Lexus's factory warranty.
Fits the following Vehicles:
- 2010-2011 Lexus RX350 | STD | 6 Cyl 3.5L | 2GRFE; GGL10L-AWTGKA, GGL10L-CWTGKA, GGL15L-AWTGKA, GGL15L-CWTGKA
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Lexus RX350 Compressor Assembly
Part Number: 88320-0E010
$388.44 MSRP: $529.60
You Save: $141.16 (27%)
Ships in 1-3 Business Days
ADD TO CART
Product Specifications
- Other Name: Compressor Assy, Cooler
- Warranty: This genuine part is guaranteed by Lexus's factory warranty.
Fits the following Vehicles:
- 2007 Lexus RX350 | STD | 6 Cyl 3.3L | 3MZFE; MCU33L-CWAGKA, MCU38L-CWAGKA
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Lexus RX350 Compressor Assembly
Part Number: 88320-48220
$689.03 MSRP: $959.37
You Save: $270.34 (29%)
Ships in 1-3 Business Days
ADD TO CART
Product Specifications
- Other Name: Compressor Assy, Cooler; Compressor
- Replaces: 88320-48170
- Warranty: This genuine part is guaranteed by Lexus's factory warranty.
Fits the following Vehicles:
- 2010-2013 Lexus RX350 | STD | 6 Cyl 3.5L | 2GRFE; GGL10L-AWTGKA, GGL10L-CWTGKA, GGL15L-AWTGKA, GGL15L-CWTGKA
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Lexus RX350 COMPRESSOR ASSY, W/M
Part Number: 88370-33051
$1116.24 MSRP: $1515.35
You Save: $399.11 (27%)
Ships in 1-3 Business Days
ADD TO CART
Product Specifications
- Other Name: Compressor, Compressor Assembly
- Replaces: 88370-33050, 88370-33040
- Warranty: This genuine part is guaranteed by Lexus's factory warranty.
Fits the following Vehicles:
- 2023-2025 Lexus RX350 | 4 Cyl 2.5L | A25AFXS; AALH15L-AWXGBA, AALH15L-CWXGBA
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Lexus RX350 Compressor Assembly
Part Number: 88320-0E050
$1567.43 MSRP: $2172.66
You Save: $605.23 (28%)
Ships in 1-3 Business Days
ADD TO CART
Product Specifications
- Other Name: Compressor Assy, Cooler
- Warranty: This genuine part is guaranteed by Lexus's factory warranty.
Fits the following Vehicles:
- 2010-2013 Lexus RX350 | STD | 6 Cyl 3.5L | 2GRFE; GGL10L-CWTGKA, GGL15L-CWTGKA, GGL15L-CWZGKA
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Lexus RX350 Compressor Assembly, W/P
Part Number: 88310-06570
$639.95 MSRP: $894.27
You Save: $254.32 (29%)
Ships in 1-3 Business Days
ADD TO CART
Product Specifications
- Other Name: Compressor
- Warranty: This genuine part is guaranteed by Lexus's factory warranty.
Fits the following Vehicles:
- 2023-2025 Lexus RX350 | 4 Cyl 2.4L | T24AFTS; TALA10L-CWZGTA, TALA15L-CWZGTA
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Lexus RX350 Compressor Assembly
Part Number: 88320-48060
$795.71 MSRP: $1102.96
You Save: $307.25 (28%)
Ships in 1-3 Business Days
ADD TO CART
Product Specifications
- Other Name: Compressor Assy, Cooler
- Replaces: 88320-48060-84
- Warranty: This genuine part is guaranteed by Lexus's factory warranty.
Fits the following Vehicles:
- 2007 Lexus RX350 | STD | 6 Cyl 3.3L | 3MZFE; MCU33L-AWAGKA, MCU38L-AWAGKA
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Lexus RX350 Compressor Assembly
Part Number: 88320-48330
$367.31 MSRP: $484.37
You Save: $117.06 (25%)
Ships in 1-3 Business Days
ADD TO CART
Product Specifications
- Other Name: Compressor
- Warranty: This genuine part is guaranteed by Lexus's factory warranty.
Fits the following Vehicles:
- 2019-2022 Lexus RX350 | STD | 6 Cyl 3.5L | 2GRFKS; GGL20L-CWZGBA, GGL25L-BWZGBA, GGL25L-CWZGBA
View related parts
Lexus RX350 Compressor Assembly
Part Number: 88320-48260
$675.95 MSRP: $876.93
You Save: $200.98 (23%)
Ships in 1-3 Business Days
ADD TO CART
Product Specifications
- Other Name: Compressor Assy, Cooler
- Replaced by: 88320-48280
- Warranty: This genuine part is guaranteed by Lexus's factory warranty.
Fits the following Vehicles:
- 2012-2013 Lexus RX350 | STD | 6 Cyl 3.5L | 2GRFE; GGL10L-AWTGKA, GGL15L-AWTGKA
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Lexus RX350 Compressor Assembly, W/MOTER
Part Number: 88370-48110
$1149.74 MSRP: $1560.81
You Save: $411.07 (27%)
Ships in 1-3 Business Days
ADD TO CART
Product Specifications
- Other Name: Compressor Assy, W/Motor; Compressor
- Replaced by: 88370-48111
- Warranty: This genuine part is guaranteed by Lexus's factory warranty.
Fits the following Vehicles:
- 2016-2022 Lexus RX350 | STD | 6 Cyl 3.5L | 2GRFXS; GYL20L-CWXGBA, GYL25L-AWXGBA, GYL25L-CWXGBA
View related parts
Lexus RX350 Compressor Assembly, W/MOTER
Part Number: 88370-48080
$1176.59 MSRP: $1633.36
You Save: $456.77 (28%)
Ships in 1-3 Business Days
ADD TO CART
Product Specifications
- Other Name: Compressor Assy, W/Motor; Compressor
- Warranty: This genuine part is guaranteed by Lexus's factory warranty.
Fits the following Vehicles:
- 2011-2015 Lexus RX350 | STD | 6 Cyl 3.5L | 2GRFXE; GYL10L-AWXGKA, GYL10L-CWXGKA, GYL15L-AWXGKA, GYL15L-CWXGKA
View related parts
Lexus RX350 Compressor Assembly, W/M
Part Number: 88370-48190
$1185.37 MSRP: $1646.35
You Save: $460.98 (28%)
Ships in 1-3 Business Days
ADD TO CART
Product Specifications
- Other Name: Compressor
- Warranty: This genuine part is guaranteed by Lexus's factory warranty.
Fits the following Vehicles:
- 2019-2022 Lexus RX350 | 6 Cyl 3.5L | 2GRFXS; GYL25L-CWXGBA
View related parts
Lexus RX350 COMPRESSOR ASSY, W/M
Part Number: 88370-48210
$3210.83 MSRP: $4450.62
You Save: $1239.79 (28%)
Ships in 1-2 Business Days
ADD TO CART
Product Specifications
- Other Name: Compressor
- Warranty: This genuine part is guaranteed by Lexus's factory warranty.
Fits the following Vehicles:
- 2023-2025 Lexus RX350 | 4 Cyl 2.4L | T24AFTS; TALH17L-AWTGTA, TALH17L-CWTGTA
View related parts
Lexus RX350 COMPRESSOR ASSY, W/M
Part Number: 88370-48220
$5905.19 MSRP: $8185.35
You Save: $2280.16 (28%)
Ships in 1-2 Business Days
ADD TO CART
Product Specifications
- Other Name: Compressor
- Warranty: This genuine part is guaranteed by Lexus's factory warranty.
Fits the following Vehicles:
- 2023-2025 Lexus RX350 | 4 Cyl 2.5L | A25AFXS; AALH16L-AWXGBA
View related parts
Lexus RX350 COMPRESSOR ASSY, W/M
Part Number: 88370-48111
$1149.74 MSRP: $1560.81
You Save: $411.07 (27%)
Ships in 1-3 Business Days
ADD TO CART
Product Specifications
- Replaces: 88370-48110
- Warranty: This genuine part is guaranteed by Lexus's factory warranty.
Fits the following Vehicles:
- 2016-2022 Lexus RX350 | STD | 6 Cyl 3.5L | 2GRFXS; GYL20L-CWXGBA, 2GRFXS; GYL25L-AWXGBA, GYL25L-AWXGBA, GYL25L-CWXGBA
View related parts
Lexus RX350 Compressor Assy, W/Pulley
Part Number: 88310-33330
$552.11 MSRP: $711.08
You Save: $158.97 (23%)
Ships in 1-3 Business Days
ADD TO CART
Product Specifications
- Other Name: Compressor Assembly, W/P; Compressor
- Warranty: This genuine part is guaranteed by Lexus's factory warranty.
Fits the following Vehicles:
- 2023-2025 Lexus RX350 | 4 Cyl 2.4L | T24AFTS; TALA10L-AWZGTA

Lexus RX350 A/C Compressor

The Lexus RX350 A/C Compressor is the heart of the climate control system and pressurizes the refrigerant to keep the cabin refreshingly cool on hot days. Inside the unit, the low pressure vapor enters and gets squeezed into a high pressure high temperature gas that then goes to the condenser where the heat leaves the flow before the chilled liquid heads to the evaporator and returns as a vapor ready for another cycle. Because constant compression and circulation powers the whole loop, a healthy A/C Compressor is a direct factor in the decision of how steady a stream of cold air will flow from the vents whenever the crossover air conditioning is switched on. Through the model years, the Lexus RX350 crossover has been based on two refrigerant approaches, early assemblies built for R12 and newer versions tuned for the greener R134a, which marked the main evolution in RX350 cooling hardware. Although both styles use the same compressor to condenser to evaporator pathway, R12 units use mineral oil while R134a versions require different lubricating agents making their A/C Compressor fittings and seals unique to each generation. Drivers selecting a replacement A/C Compressor need to ensure that the correct refrigerant layout and model code specified for their Lexus is matched to the compressor to prevent leaks or poor performance. Understanding these differences allows any Lexus RX350 owner to appreciate how the proper A/C Compressor keeps you comfortable during each summer commute.

Should you need to purchase new auto parts for your vehicle, we strongly suggest you consider the genuine Lexus RX350 A/C Compressor available on LexusPartsNow.com. Our OEM Lexus RX350 A/C Compressor come with the reassurance of the manufacturer's warranty, a hassle-free return policy, and speedy delivery service, all at affordable prices online. Feel free to shop with confidence!

Lexus RX350 A/C Compressor Parts Questions & Experts Answers

Compressor Assy, W/Motor
88370-48030
Q: How to remove and install A/C Compressor on Lexus RX350?
A:
The receiver/drier should be replaced whenever the compressor is replaced. First, have the refrigerant discharged by an automotive air conditioning technician. Next, disconnect the negative cable from the battery. Remove the drivebelt from the compressor and take off the splash shield from below the engine compartment, if equipped. For 2003 and earlier Lexus models, remove the alternator. For 2008 and later Highlander models and 2009 and later RX 350 models, remove the Radiator. Detach the wiring connector and the refrigerant lines, then unbolt the compressor and lift it from the vehicle. If a new or rebuilt compressor is being installed, follow the directions that come with it regarding the proper level of oil prior to installation. Installation is the reverse of removal; replace any O-rings with new ones specifically made for the purpose and lubricate them with refrigerant oil. Finally, have the system evacuated, recharged, and leak tested by the shop that discharged it.